The White Sox open with three exhibition games: two against the Cubs and one against the Brewers. The first regular season game opens with a series in Chicago versus the Minnesota Twins. The season ends with three home games against the Cubs, so if either the Sox or Cubs are vying for a playoff slot, that will be a series for the ages.
The breakdown of the schedule is: 10 games with Minnesota, 10 with Kansas City, 10 with Detroit, 10 with Cleveland, 4 with Milwaukee, 4 with Pittsburgh, 3 with St. Louis, 3 with Cincinnati, and 6 with the Chicago Cubs. Keep in mind, Illinois Governor J.B. Pritzker has notably said Chicago outdoor sporting events can be played in front of 20% of stadium capacity. Chicago Mayor, Lori Lightfoot, has yet to approve fans in stadiums. The MLB will most likely make a decision on where or not fans can attend games, depending on COVID-19 risk. The Sox have a chance to make an impact with one of the easier schedules in the league.